NFAM1 Antibody, FITC conjugated

Datasheet

Code	CSB-PA850874LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NFAM1 Polyclonal antibody

Uniprot No.

Q8NET5

Target Names

NFAM1

Alternative Names

NFAM1 antibody; CNAIPNFAT activation molecule 1 antibody; Calcineurin/NFAT-activating ITAM-containing protein antibody; NFAT-activating protein with ITAM motif 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human NFAT activation molecule 1 protein (186-270AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.

Gene References into Functions

CNAIP is a ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway and the downstream cytokine gene promoters PMID: 12615919
Our results demonstrate NFAT expression and activation in native human vessels and point out A-285222 as a powerful pharmacological blocker of NFAT signaling in the vasculature. PMID: 17079331
NFAT plays a role in SV40 infection via transcriptional control of Simian Virus 40. PMID: 18031784
Our findings define a pathway involving CD28 binding to Grb-2 and its co-operativity with Vav1 in the regulation of T-cell co-stimulation. PMID: 18295596

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue.

Database Links

HGNC: 29872

OMIM: 608740

KEGG: hsa:150372

STRING: 9606.ENSP00000333680

UniGene: Hs.436677

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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